Source Naturals L-Carnosine 500mg - 30 Tablets

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500mg - 30 Tablet

Product Overview

500mg - 30 Tablets
Reduces Glycation
 
 
Carnosine is a small molecule composed of the amino acids histidine and alanine. This dipeptide is found in relatively high concentrations in several body tissues—most notably in skeletal muscle, heart muscle, skin, stomach, nerve tissue and brain. The exact biological role is not well understood, but many studies indicate that Carnosine has antioxidant potential. Carnosine may also act as a neurotransmitter (chemical messenger in the nervous system).
 

Carnosine is a multifunctional dipeptide made up of amino acids beta-alanine and L-histidine. It’s found both in food and in the human body. Long-lived cells such as nerve cells (neurons) and muscle cells (myocytes) contain high levels of carnosine.30 Muscle levels of carnosine correlate with the maximum life spans of animals. Carnosine has a number of antioxidant properties and has been shown to be an anti-glycating agent.1-7

This nutrient has the ability to suppress formation of advanced glycation end products (AGEs) and reactive oxygen species (ROS),8-11 culprits in metabolic dysfunction and oxidative stress that possibly can lead to age-related conditions.42-44Carnosine levels decrease with age. Muscle levels decrease 63% from age 10 to age 70, which may account for the normal age-related decrease in muscle mass and function. 12

Since carnosine acts as a pH buffer, it can keep on protecting muscle cell membranes from oxidation under the acidic conditions of muscular exertion. Carnosine enables the heart muscle to contract more efficiently through enhancement of calcium response in heart myocytes. 13

Aging causes irreversible damage to the body’s proteins. One underlying mechanism behind this damage is glycation. Glycation involves the non-enzyme controlled cross-linking of proteins or lipids and sugars to form non-functioning structures in the body. The process of glycation can be superficially seen as unsightly wrinkled skin. Glycation is also an primary cause of age-related neurologic, vascular, and eye problems. 14-25 Carnosine is a unique dipeptide that can interfere with the glycation process.1-7
 
Suggested Use: 1 to 3 tablets daily with meals. Best if spread over separate eating occasions.
 

 Supplement Facts

 Serving Size: 1 Tablet

 Servings Per Container: 30

                                                   Amount/Serving    %DV

 

 Calcium                                                  88 mg              9%

 L-Carnosine                                          500 mg              *

 

 * Daily Value not established
 

Other Ingredients: dibasic calcium phosphate, microcrystalline cellulose, stearic acid, hydroxypropyl cellulose, silica, and modified cellulose gum.

Warning: If you are pregnant, may become pregnant, or breastfeeding, consult your physician before using this product.
Do not use if either tamper-evident seal is either broken or missing. Keep out of the reach of children.
Suitable for vegetarians.

 

                        References

 

  1. Arch Biochem Biophys. 2004 Jul 1;427(1):110-5.
  2. Exp Gerontol. 2009 Apr;44(4):237-42. Epub 2008 Nov 11.
  3. Ann N Y Acad Sci. 2002 Apr;959:285-94.
  4. Biosci BiotechnolBiochem. 2002 Jan;66(1):36-43.
  5. Nephron Clin Pract. 2007;107(1):c26-34. 
  6. Perit Dial Int. 2007 Jan-Feb;27(1):86-9.
  7. Ann N Y Acad Sci. 2006 May;1067:369-74.
  8. Protein J. 2011 Mar;30(3):149-58. 
  9. Acta Biol Hung. 2009 Jun;60(2):137-48. 
  10. Front Aging Neurosci. 2010 Mar 18;2:10. 
  11. Free Radic Biol Med. 2010 Mar 1;48(5):727-35. 
  12. Arch Gerontol Geriatr. 1999 Sep-Oct;29(2):107-13.
  13. Am J Physiol. 1997 Jan;272(1 Pt 2):H462-8.
  14. Diabetologia. 2002 Oct;45(10):1457-62.
  15. Pathol Biol (Paris). 2003 Dec;51(10):543-9
  16. Brain Res Brain Res Rev. 2003 Mar;41(2-3):306-23.
  17. Arthritis Rheum. 2004 Apr;50(4):1207-15.
  18. Med Hypotheses. 2004;62(2):275-9.
  19. Can J Physiol Pharmacol. 2000 Oct;78(10):848-55.
  20. Ann N Y Acad Sci. 2001 Apr;928:48-53.
  21. Arthritis Rheum. 2002 Jan;46(1):114-23.
  22. J InvestDermatol. 2002 Aug;119(2):489-98.
  23. Kurume Med J.2002;49(1-2):7-13.
  24. Curr Pharm Des. 2008;14(10):946-52.
  25. Metabolism. 2008 Oct;57(10):1452-7.

 

*These statements have not been evaluated by the FDA. This product is not intended to diagnose, cure or prevent any disease.

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